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Upon ligand binding, TR II phosphorylates and activates TR I, forming a heteromeric receptor complex that initiates downstream signaling through both SMAD-dependent and SMAD-independent pathways, such as ERK, p38, JNK, and PI3K-Akt cascades [33, 36, 39]

Reverse transcription of miRNA was performed using the Hairpin-it miRNAs qPCR Quantitation Kit (GenePharma, Shanghai, China), following the manufacturers protocol

Additionally, intravenous administration of the endogenous peptide apelin-13 can significantly reduce BBB permeability and vasogenic edema by targeting oxidative stress during ischemia-reperfusion

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Through integrating findings from recent studies, this work aims to shed light on the potential of microbiota-targeted therapies in managing diseases that involve the gut, liver, and kidneys (Guo et al., 2 Composition and function of gut microbiota The gut microbiota, a diverse community of microorganisms living in the gastrointestinal tract, is vital for human health

The at-home version trades that consistency for convenience and cost