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There are some reports showing that angiogenesis inhibitors could not support therapeutic effect in previously treated metastatic breast cancer [187]

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10.1038/s41398-025-03372-w 304 MakkawiS.Camara-LemarroyC.MetzL

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This dosage results in a dose-dependent increase in plasma concentrations of UroA and its glucuronide and sulfate conjugates, supporting its physiological activity in target tissues, particularly muscles and their mitochondria (Reference Andreux, Blanco-Bose and Ryu14)