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In the CNS, mitochondrial function is essential for sustaining neuronal energy balance, thereby supporting synaptic activity and neuron viability

N-terminally truncated isoforms (N) lack the transactivation domain and appear to act in a dominant-negative manner by either competing with the TA isoforms of p63 and p53 for DNA binding sites or by direct protein interaction

Vertigo is a condition characterized by the false sensation of movement, such as spinning, swaying, or tilting

LD functions by replenishing dopamine stores in the brain, reversing the PD symptoms that result from an imbalance of neurotransmitters

They also observed that resveratrol increased SIRT2 levels, upregulated the mRNA expression of glycolysis- enhancing enzymeshexokinase 2 (HK2), lactic dehydrogenase A (LDHA), and pyruvate kinase M2 (PKM2)and shifted the concentration of glycolytic products (reduced pyruvate and elevated lactate), promoting glycolysis (45)