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doi: 10.1128/jvi.61.3.858-865.1987

[2] For more persistent or severe acne, your GP may prescribe oral antibiotics (such as lymecycline or doxycycline) for up to 12 weeks, alongside appropriate topical treatments

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A curto prazo, pode haver sobrecarga no fgado, rins e outros rgos, mas com o passar do tempo, pode haver a ocorrncia de doenas mais graves, como cardiovasculares e neurolgicas