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Eur J Medicinal Chem Rep

Alpha-Lipoic Acid - Uses and Risks

These findings suggest that a GST tag is not an authentic TG2 substrate but instead is accidentally crosslinked by TG2 during cell lysate incubation

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This forms a pathogenic positive feedback looplinking iron accumulation, A/tau pathology, and ferroptosiswhich collectively exacerbate neuronal injury (Yadav et al., 2023