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Interestingly, Insr P1195L/ + mice were extremely susceptible to overt hyperglycemia by HFD

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Thus, in the metabolic transformations of the pentose phosphate pathway, part of the energy of glucose 6-phosphate is conserved in NADPH, a molecule with a negative reduction potential, that, therefore, can be used in reactions requiring an electron donor, such as fatty acid and steroid synthesis

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