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Intestinal microbiota regulates the gut-thyroid axis: the new dawn of improving Hashimoto thyroiditis

[,] In an in vitro experiment using TRAMP C1 cells, SFN was found to cause epigenetic modifications in the expression of several HDAC proteins, thereby restoring Nrf-2 expression

AMPK serves as a central regulator, influencing downstream targets such as eukaryotic translation initiation factor 4E-binding protein 1 (eIF-4E-BP1), glutathione peroxidase 7 (GPx7), mechanistic target of rapamycin (mTOR), nuclear factor erythroid 2-related factor 2 (Nrf2), and nuclear factor-kappa B (NF-kB)

Seok-yoons team Pladen Clinic, Sinsa, Seoul

Wolf, Y

84, 183 (2010).CrossRefGoogle ScholarPubMed Yu, Y., Duan, J., Li, Y., Li, Y., Jing, L., Yang, M., Wang, J., and Sun, Z.: Silica nanoparticles induce liver fibrosis via TGF-1/Smad3 pathway in ICR mice