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The authors suggest that one of more yet unidentified iron-dependent enzymes are functioning as a core lethal mechanism for ferroptosis (Dixon et al., Future cancer prevention and cancer therapeutics It is generally accepted that chronic oxidative stress via excess iron leads to carcinogenesis, presumably through hydroxyl radicals, and that most of the defense system is associated with thiol compounds whereas iron and thiol compounds are apparently essential elements

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RavJ harbors an C 101 H 138 D 170 motif associated with human tissue transglutaminases (TGs)

An elastase-induced rat IA model was established as previously described, with in vivo measurements of aneurysm incidence, rupture rates, and artery structural integrity

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4. Rinse thoroughly with water