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This waning of efficacy is also observed for booster vaccination when Omicron is the dominant circulating variant, with Menegale et al

It's going to be really tough

The observed increase in mitochondrial malate and cytosolic 2-oxoglutarate through elevated SLC25A11 expression aligns with the systemic energetic dysregulation and oxidative stress reported in plasma metabolomic studies in ME/CFS patients