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I-BET151 (a selective inhibitor of BET) can reduce joint inflammation and bone loss by blocking MMP-1, MMP-3, IL-6, and IL-8 production in RA FLS (190, 306)

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Macromolecules can be sampled from the intestinal lumen into enterocytes by a vesicular transport (fluid phase or receptor-mediated endocytosis) and released basolaterally

91% of users maintain results through week 48

Slow down stomach emptying, retaining a sense of fullness for longer