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Although this approach showed promising ideas, the authors pointed out that kidney organoids in general resembled a rather immature form of the kidney and the Gb3 deposition with subsequent tissue damage in the patient takes a much longer time than the 3-week cultivation of these in vitro models

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However, Khameneh et al

We followed the criteria proposed by the 2004 US Surgeon General Report on the health consequences of smoking [32], which include the evaluation of consistency, temporality, strength, dose-response relationship, and biological plausibility including confounding