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S-specific IgG4 was undetectable in most vaccinees after the first and early after the second vaccination but reached almost 20% of the IgG response late after the third vaccination

Nonetheless, this work has identified novel findings that support future studies to determine whether microbiome changes are contingent upon the combination of both NNMTi and LD switch and mediated through direct NNMTi-driven mechanisms or through indirect mechanisms such as weight or fat loss 8,13

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Women tend to experience more gastrointestinal side effects at each dose level in clinical trial data, though the difference is not large enough to warrant a different escalation schedule