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Novel homodimer metabolites of GDC-0994 via cytochrome P450-catalyed radical coupling Source: Drug Metab Dispos

M., Ultsch, M

Cavalcante AA, Campelo MW, de Vasconcelos MP, Ferreira CM, Guimares SB, Garcia JH, de Vasconcelos PR

By keeping healthy cells safe, it allows patients to complete their full course of treatment with less pain and fewer complications

doi: 10.1042/CS20130339 34 De MauriACarreraDBagnatiMRollaRVidaliMChiarinottiDet al

Furthermore, the model demonstrated increased resistance to cerulenin, a fatty acid synthase inhibitor, and lower levels of condensing enzymes linked to the synthesis of very long-chain fatty acids (Visram et al., 2018)