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Much of the research done to examine links between antidepressant drugs and mitochondrial function have used the SSRI fluoxetine, which may either inhibit or trigger mitochondrial apoptosis and alter activity of the ETC, depending on the cell type ( in vitro inhibited state 3 of mitochondrial respiration for -ketoglutarate and succinate oxidation, stimulated state 4 for succinate, and decreased the respiratory control ratio for both oxidizable substrates (Souza et al., 1994)

10.1089/ten.tea.2018.0308 175 SiegelR

One in four pts with the lowest AUDIT tertile showed elevated PEth, indicating false negativity of AUDIT

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Available evidence suggests a role for voltage-dependent anion channel (VDAC), located in the OMM, and adenine nucleotide translocase (ANT) across the IMM ( 2 + -induced swelling and MPT, although at a higher threshold, which has been interpreted as evidence against a role for ANT in MPT (Sileikyte et al., 2014)