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These components, collectively known as the neurovascular unit (NVU), work together to support the normal functioning of the central nervous system

In animal experiments, researchers have found that the inactivation of Ubiquitin-Specific Peptidase 25(USP25) can alleviate oxidative liver injury induced by acetaminophen (APAP) overdose in male mice and reduce mortality caused by lethal doses of APAP

After washing once with PBS to remove unbound CFSE, SFN was added for 30 min and the cells were seeded on 96-well microplates coated with anti-CD3/CD28 antibodies for co-stimulation as described above

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Morroniside protects dopaminergic neurons from ferroptosis in PD by activating the Nrf2 pathway and upregulating expression of GPX4 and SLC7A11

For our study, we chose the 15 SPD method as the best compromise of the depth of coverage and throughput