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Additionally, evobrutinib is a new and highly specific antagonist of Brutons tyrosine kinase (BTK) that has yielded encouraging outcomes in phase II clinical trial for relapsing MS, SLE and RA [63, 64]

10.3389/fcimb.2023.1062963 57

Caughey WS, Hellerman L, Smiley JD

hence it is expected to be a novel therapeutic tool for the metabolic syndrome

CD271 is associated with stemness, clonogenic potential, and tissue tropism, which may have an impact on stronger tissue-repair signaling, and its reduction during passaging or expansion could lead to a decrease in the therapeutic efficacy of MSCs-derived EVs (49)