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Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells

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Histamine influences the expression of the interleukin-6 receptor on human lymphoid, monocytoid and hepatoma cell lines

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This phenomenon supports the notion that increased oxidative stress is an important pathogenic mechanism of HCC [2,3,5], and suggests that GSH might be utilized and oxidized to GSSG in order to cope with increased oxidative stress during the development of HCC