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These agents are useful in treatment of metastatic kidney cancer, but as for other anticancer drugs, resistance develops with continued use, through mechanisms not yet fully defined

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Furthermore, inhibiting TLR4 can also modulate gut microbiota homeostasis and the MyD88/NF-B axis in ulcerative colitis (164), indicating that TLR4 acts not only as a key sensor of innate immunity but may also regulate neuroimmune crosstalk and gut microenvironment homeostasis