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Additionally, GPxs due to their subcellular compartmentalization (cytoplasmic, membrane, ER, and mitochondrial localizations) control the local concentration gradient of peroxides and thereby regulate the activation/deactivation of redox-responsive signaling pathways [1, 8,9,10]

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Stacking them together makes sense

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Also, the effect of lactobacillus on the natural immune response of rainbow trout was also enhanced under the effect of selenite ( 2 The role of selenoproteins in the antioxidant system of aquatic animals In general, Se sources in animals will first be converted into selenides for play on organisms and then will be converted into proteins containing selenocysteine (Sec), that is, selenoprotein which then will be absorbed and used by organisms ( It has been found that the thioredoxin reductase system and glutathione peroxidase system play an important role in cellular oxidative stress defense ( 2- ), H 2 O 2 , and hydroxyl radicals (OH )

Info Sogenannter oxidativer Stress kann dafr sorgen, dass Glutathion in Krperzellen vermehrt in inaktiver (oxidierter) Form vorliegt