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However, the efficient synthesis of heme might lead to excessive accumulation of heme in the cell, which would produce cytotoxicity, thus inhibiting the strain growth, which is counterproductive for heme synthesis

It can also interact with medications for depression and hypertension (high blood pressure)

A Raf-like MAPKKK gene DSM1 mediates drought resistance through reactive oxygen species scavenging in rice

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Bcl2: B-cell lymphoma protein 2

For people with high cardiovascular risk, the NSAID naproxen is typically recommended because it has been associated with fewer cardiovascular events compared with other NSAIDs in several studies (Conaghan 2012)