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Nobiletin and tangeretin belong to the group of polymethoxyflavonoids, found in the peel extract of Citrus depressa (Jang et al., 2013)

FIGURE 2 Ophthalmic acid (OPH), formed via reaction of -glutamylcysteine and glutathione synthase, has been suggested to be a biomarker of oxidative stress in cells and tissues following depletion of cellular glutathione (Figure 2D) in ER-treated WT (p-value = 4.3 10 8 , fold change = 18) and R (p-value = 1.0 10 10 , fold change = 34) cells

FIGURE 2 Additionally, oxidative stress can induce insulin resistance by impairing insulin signal transduction and causing adipokine dysregulation, leading to systemic glucose and lipid metabolism disorders

N l mt tri-peptide c tng hp t t bo bng 3 amin gm cysteine, glutamic v glycine vi nhng tc dng chnh l: + Glutathione gip xy dng, sa cha m, to ra cc ha cht v protein cn thit trong c th v cho h thng min dch