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Thus a reduction in a protective antioxidant such as UA may result in increased oxidative stress and subsequent damage

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Oxidative stress typically results from the overproduction of free radicals, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), which are generated by internal metabolic processes and external environmental factors like ultraviolet radiation, chemical pollutants, and physical overexertion [2] Studies have shown a direct correlation between excess free radicals, DNA damage, cancer cell growth, type II diabetes mellitus induction and many other deviations [3, 4]

doi: 10.1021/acschemneuro.0c00323 390 QuatranaAPetrilloSTordaCDe SantisEBertiniEPiemonteF