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Alpha-lipoic acid (ALA) mitigates ferroptosis by activating the PPAR/NRF2/GPX4 pathway, enhancing antioxidant defenses, and improving pregnancy outcomes in unexplained RM

10.1007/s11357-012-9484-9 113 ShiF.ZhangP.MaoY.WangC.ZhengM.ZhaoZ

Discussion In this study, we demonstrate that replication fork reversal and chromosome mis-segregation induced by HRASV12 or cyclin E1 overexpression are mainly caused by R-loops that appear to form specifically in S-phase, possibly during transcription-replication encounters