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Mutations, amplifications, and overexpression of PIK3CA, KRAS, AKT, IGFR and EGFR upstream of mTORC1 are very common in human malignancies

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Although dietary interventions modulate the energetic substrate supply to tumors only to a limited extent, they offer significant ancillary benefits by imposing hormonal states that burden cancer metabolism, enhancing immune responses, and reducing inflammation

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