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P-glycoprotein (P-gp or ABCB1), a member of a large family of ATP Binding Cassette (ABC) transporters, mediates the active efflux of anticancer drugs [4]

Pediatric patients and those with delayed presentations of clinical cholestasis of undetermined etiology, or a family history of cholestatic disease, should be considered for NGS or WES genetic testing

In NPC1-deficient mice and several phase 1/2a trials, both intrathecal and intravenous administration [7,8,9] of HPCD reduced cholesterol accumulation with beneficial effects for neurological symptoms, and improved liver dysfunction [7, 70]

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Rosenberg, J., Ischebeck, T

See How South African Actress Khanyi Mbau Lightened Her Skin Beyond Recognition We have a lot of feelings when it comes to skin bleaching