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This leads to an amplification of painful sensations throughout the body, making even mild stimuli feel intensely painful

PLoS Biol 3:e375 Seiler A, Schneider M, Frster H et al (2008) Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

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J Biol Chem (2001) 276:1922030

The reaction occurs at a given pH, and the reacting compounds are in equilibrium with this pH and thus giving off or receiving a proton has no effect on the energetics

In these cases, the organism has difficulty returning to equilibrium, with HPA axis maladjustment and increased inflammation