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L.BeattieJ.DavatiC.FlintR.et al (2019)

Mol Pharmacol 21:629631 Conigrave AD, Hampson DR (2006) Broad-spectrum L-amino acid sensing by class 3 G-protein-coupled receptors

Graphical abstract Access this article Similar content being viewed by others Abbreviations C10-Br-CNCbl: CNCbl brominated at C10-position of corrin ring C10-Br-H 2 OCbl: H 2 OCbl brominated at C10-position of corrin ring Cbi: Cobinamide Cbl: Cobalamin CNCbl: Cyanocobalamin DMBI: 5,6-Dimethylbenzimidazole GSCbl: Glutathionylcobalamin GSH: Glutathione H 2 OCbl: Aquacobalamin C10-Br-SO 3 Cbl: Sulfitocobalamin brominated at C10-position of corrin ring References Derevenkov IA, Salnikov DS, Silaghi-Dumitrescu R, Makarov SV, Koifman OI (2016) Redox chemistry of cobalamin and its derivatives

doi: 10.1159/000362989 123 MallelaSKMitrofanovaAMerscherSFornoniA

Interestingly, it has been reported that OGT and Ezh2 co-repress a defined tumor suppressor genes in breast and colon cancer cells

R Met/Met individuals have higher synaptic dopamine and norepinephrine (because COMT clears them more slowly), which improves prefrontal cortex function and working memory but increases susceptibility to stress-related anxiety, pain sensitivity, and catechol estrogen accumulation