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2013;17(Suppl 1):S367-S373

For these initial efficacy studies, we elected to test drugs with one dose of ionizing radiation rather than conducting fractionated radiation doses to minimize tissue damage and animal stress

Moreover, increased expression of interferon- (IFN-), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor-1 (TGF-1), IL-8, IL-6, and TNF- and other genes associated with the immune response have been reported in those brain regions and in the cerebrospinal fluid [4850] (Figure 4)

Immunotherapeutic maintenance treatment with toll-like receptor 9 agonist lefitolimod in patients with extensive-stage small-cell lung cancer: Results from the exploratory, controlled, randomized, international phase ii impulse study

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