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[0001842] Administered in combination: As used herein, the term "administered in combination" or "combined administration" means that two or more agents are administered to a subject at the same time or within an interval such that there may be an overlap of an effect of each agent on the patient

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J Neuropathol Exp Neurol 65(6):56270 Booij L et al (2005) The effects of high-dose and low-dose tryptophan depletion on mood and cognitive functions of remitted depressed patients

If needed, B12 can be replaced with supplements or injections, under medical supervision

doi: 10.3389/fphar.2025.1528208 Received 14 November 2024 Accepted 02 April 2025 Published 10 April 2025 Volume 16 - 2025 Edited by Yanggan Wang, Wuhan University, China Reviewed by Yi Zhu, Chengdu University of Traditional Chinese Medicine, China Baonian Liu, Shanghai University of Traditional Chinese Medicine, China Updates Copyright 2025 Chen, Fu, Zhou and Wu