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[12,13] Nonetheless, AZT also has potent anti-inflammatory and antioxidant activities while protease inhibitors (PIs) like ritonavir (RTV) have demonstrated a protective role in an animal model of HIV-PH [14,15] Likewise, several translational studies have shown the beneficial effect of ARVs medications in HIV-PH risk reduction and the variable outcomes among established early-stage HIV-PH patients