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A mechanism by which mitochondrial dysfunction contributes to aging and neurodegeneration is via a net increase in the production of ROS (Zhu et al., 2013)

Dho SH, Cho M, Woo W, Jeong S, Kim LK (2025) Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond

Regulation of cytochrome C oxidase contributes to health and optimal life

Zinc is a cofactor for the antioxidant enzyme superoxide dismutase that converts superoxide to hydrogen peroxide, as shown below

210 In addition, apoptosis has been observed not only in neuronal cells but also in astrocytes

Embryogenic tissues exhibited meristematic cells that were small, cytoplasm-dense, and possessed prominent nuclei, whereas non-embryogenic callus consisted of large, highly vacuolated, isodiametric cells