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TAS2Rs are also distinct in containing highly conserved TMD regions, with thirteen key residues and two motifs (LXXXR in TMD2 and LXXSL in TMD5) that are absent in class A GPCRs, and may reflect their different activation mechanisms (Singh et al., 2011)

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42 Technical Considerations In this study, three kinds of experiments, including measurement of motor nerve responses and sensory thresholds histopathological evaluation of the sciatic nerve, were performed to show the short-term effects of the PGA-collagen tube for nerve injury in continuity using a sciatic nerve injury rat model