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Tissues were embedded in paraffin, sectioned, and stained with hematoxylin and eosin (H&E) by the University of Texas Southwestern Histo Pathology Core

Selenium: This mineral is a structural component of glutathione peroxidase, an enzyme that helps glutathione do its job

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Hyperglycemia acts as both an initiator of oxidative stress and a co-promoter of pathogenic molecular pathways, and cross-talk among these pathways induces ROS amplification via positive feedback, exacerbating oxidative damage, BRB impairment, iron dyshomeostasis and DR progression (157, 158)

Cardiovascular safety No RCTs or open-label studies have demonstrated an increase in myocardial infarction (MI) rates in patients receiving PDE5Is

Relations between two sets of variates