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Chromatin insulators derived from the chicken hypersensitive site-4 (cHS4) of the -globin locus [166] were thus introduced into -globin LVs, to increase efficacy and safety [148], [167]

Whilst the quantities are minuscule and generally harmless, individuals with impaired kidney function may theoretically have reduced capacity to eliminate this cyanide with very high doses over extended periods, though this remains largely theoretical at normal supplemental doses

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Furthermore, ozone is approximately 10 times more soluble in water than regular oxygen, enabling it to interact effectively with body tissues and fluids

10.1016/j.bioactmat.2020.06.022 236 SunK.YanC.DaiX.ShiY.LiF.ChenL.et al (2024)