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Acknowledgments The authors would like to thank the University of Iowa Viral Vector Core and Central Microscopy Research Facilityespecially Jian Shaofor technical assistance

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22-23] Based on these findings, the CAFC disagreed that a skilled person would have believed that the process described in the 779 Patent would be a promising method of eliminating ABUKs

doi: 10.1016/j.nbd.2023.106200 28 Huntemer-SilveiraA.PatilN.BricknerM

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Brigelius-Floh, R., Traber, M