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Following structural damage and functional impairment of the muscle tissue, myofibrillar rupture and extravasation of intracellular proteins such as myoglobin, creatine kinase (CK), and lactate dehydrogenase (LDH), into the extracellular medium, trigger the local inflammatory response [47, 50,51,52]

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Instead, some animal experiments and clinical trials have suggested that TZDs might improve ventricular structure or function