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Trontinemab, an anti-amyloid monoclonal antibody fused to a transferrin receptor-binding shuttle module designed to enhance receptor-mediated transcytosis, is currently being evaluated in Phase I/II clinical studies, with early data indicating substantially increased brain exposure compared with conventional antibodies ( It is worth noting that an important limitation in the translation of preclinical findings to humans is the heavy reliance on transgenic mouse models, particularly APP/PS1 and 5xFAD

2009 Jun;329(3):1110-6

It is this open structure that makes ice less dense than liquid water

He coined the term vitamin from vita (life) and amine (nitrogen-containing compound), a nitrogenous substance that is important for life [50]

It is currently being studied as a combination therapy with GLP-1 receptor agonists , such as semaglutide and retatrutide, showing synergistic effects in weight management trials

They should not be relied upon and may be subject to change without notice