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As a result, we are working on constructing mice with a specifically targeted knockout of SLC1A4 in organs such as the liver, ovary, and heart

166 , considering that cancers exhibit low pyruvate kinase activity but, on the other hand, are avid lactate producers and lactate may only originate from pyruvate, where does pyruvate come from

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Lieu, C, Yu, G, Kopetz, S , Puhalla, S, Lucas, PC, Sahin, IH, Deming, DA, Philip, PA, Hong, TS, Rojas-Khalil, Y, Loree, JM, Wolmark, N, Yothers, G, George, TJ, Dasari, NV

On the contrary, SerpinB2 depletion in macrophages kindled pro-inflammatory cytokine production with concomitant high oxidative phosphorylation and apoptosis of VAT resident macrophages, indicating the role of SerpinB2 in controlling exaggerated mitochondrial respiration, inflammation, and VAT resident macrophage survival in obesity