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Oxidative stress and hypoxia modulate cellular networks via transcriptional regulators, such as HIF-1-mediated induction of BNIP3/NIX, to promote mitophagy, [] as well as through direct protein modifications, such as the redox-sensitive oligomerization of MFNs that regulates mitochondrial fusion

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TABLE 2 Formulation and dosage regimes for treatment of vitamin B12 deficiency, subdivided into congenital and acquired causes

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