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OA is characterized by progressive loss of cartilage extracellular matrix (ECM) and pathological changes in other joint tissues such as subchondral bone sclerosis, osteophyte formation, and synovial inflammation 31

In response to these dangerous cytokines, the Nuclear erythroid-2-related factor-2 (Nrf2) pathway is turned on [12]

Over time, factors like pollution, stress, UV exposure, and aging can deplete natural glutathione levels, leading to hyperpigmentation, dullness, and uneven skin tone

Key Takeaways Glutathione is an antioxidant that reduces melanin production, improving skin tone and offering various skin health benefits

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