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Moreover, following ACMG guidelines (Richards et al., 2015) a large proportion of variants can be classified as of uncertain significance (VUS) or benign, without considering their additive burden in shaping polygenic phenotypes

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TLC-2716 and TLC-6665 demonstrated comparable binding to and repression of LXR and LXR activity with half-maximal effective concentrations (EC 50 ) of 715 and 1417 nM, respectively (Fig

Despite recent developments in the field of metal-based catalytic drugs, these compounds are generally associated with a poor spatial and temporal control of the treatment as well as poor cancer selectivity, resulting in potential side effects and non-ideal drug doses 29

During viral RNA synthesis, notable structural rearrangements occur in this complex to accommodate the RNA 114

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