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From a mechanistic perspective, the cardioprotective effects of UA were revealed to be contingent upon the PI3K/Akt signaling pathway, with the use of LY294002 effectively negating its protective benefits (82)

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Mol Cell 31:143151 Zhang M, Huang N, Yang X, Luo J, Yan S, Xiao F, Chen W, Gao X, Zhao K, Zhou H et al (2018a) A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis

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