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This is considered in favor of the independent contribution of metabolic syndrome and its components (obesity, dyslipidemia, and hypertension), besides the hyperglycemia, to the onset and progression of DPN in T2D (33, 45, 107, 108)

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Clinical experience with the administration of two 37.5 mg/25 mg tablets daily in divided doses (rather than as a single dose) suggests an increased risk of electrolyte imbalance and renal dysfunction