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Loss of PPAR function in hepatocytes initiates DNA hypermethylation of genes related to fatty acid, bile acid, and steroid hormone receptors, including PPAR, leading to progression of disease [339]

In particular, older people also have chronic low-grade inflammation, so antioxidants should be carefully applied

Dysregulated metabolism contributes to oncogenesis

Notably, compared with the HG group, DAPA and Fer-1 treatment improved the decreased expression of GPX4 (Fig

This depletion may impact the body's ability to combat oxidative damage, making it essential to support optimal glutathione levels through diet, lifestyle choices, and high-quality supplementation

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