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As in T2D, APD-induced increases in circulating insulin are hypothesized to desensitize insulin-sensitive peripheral targets (e.g., liver, skeletal muscle, adipose tissue) over time, resulting in insulin resistance and weight gain 3,4,15

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These enzymes efficiently convert various nitriles, including 4-cyanopyridine, iminodiacetonitrile, and mandelonitrile, with high yields and with rapid reaction times