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Eur J Dermatol 6:184190

FIGURE 2 4.1 Nrf2 and oxidative stress Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important intracellular transcription factor and regulator of the antioxidant response, which is involved in ATO-induced oxidative liver injury (Yang et al., 2017a)

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As mentioned above, the first is stimulation of the AT1 receptor by angiotensin II which further activates phospholipase C and its activation leads to an increase in cytosolic Ca 2+ concentration

Since the discovery of the genetic etiology of AS, extensive efforts have been devoted to the understanding of the underlying mechanisms of AS pathophysiology, mainly by utilizing the AS mouse model, which was shown to replicate multiple phenotypes of the human disorder [5, 6]

Front Microbiol (Internet) 14, 1096826.CrossRefGoogle ScholarPubMed Karthik, Y, Kalyani, MI, Krishnappa, S, et al