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doi: 10.1038/s41598-024-69512-2 50 LiuX.LiuJ.ZhangT.WangQ.ZhangH

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If CNS penetration has not been quantified through CSF sampling or blood-brain barrier permeability assays, treat the peptide as potentially CNS-active and apply full neuropeptide interaction protocols staggered dosing, conservative peptide dose (5070% of standalone effective dose), and behavioral monitoring for serotonergic excess

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