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However, excellent SOD activity alone is not sufficient to scavenge excessive ROS, and carbon-dot nanozymes with multiple cascade-like activities are of greater value for further research and development

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T cell populations in CKD exhibit a shift toward pro-inflammatory phenotypes, with reduced regulatory T cell function, which fails to suppress excessive immune responses, thereby sustaining inflammation and tissue injury ( FIGURE 2 Dysbiosis of the gut microbiota leads to the disruption of tryptophan metabolism (resulting in the production of toxins such as IS and the entry of lipopolysaccharides (LPS) into the bloodstream (40)

however, because of the higher presence of intracellular proteins (cytoskeletal proteins in the T cell and CAR-T cell cocultures and mitochondrial proteins in the TCR-T cell cocultures), we applied a less stringent cutoff (10% instead of 5% FDR) (Supplementary Fig

All statistical analyses were performed using RevMan 5.4.1 and Stata 15.0