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Additionally, piperacillin-tazobactam is a substrate for OAT1 and OAT3, competitively decreasing tubular secretion of creatinine, and causing pseudo-toxicity due to rising serum creatinine levels without tubular damage

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References Jzwiak M, Bauer M, Kamysz W, Kleczkowska P

10 These detailed studies further highlight the complexity of the mucosal barrier properties and reveal that alterations in cytoskeletal proteins and TJ-integral and -associated proteins can affect mucosal permeability as well as epithelial cell homeostasis