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Glucose Metabolism and Insulin Sensitivity IGF-1 plays a critical role in glucose homeostasis and insulin sensitivity through both direct and indirect mechanisms

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It is important to note that the neurogenesis hypothesis of depression is somewhat controversial because depression-like symptoms can occur even when cell proliferation is not decreased and the behavioral actions of antidepressants do not always coincide with increases in the number of hippocampal neurons (Surget et al., 2008